Spectral clustering of fMRI data within regions of interest: clarification of L-dopa effects in Parkinson's disease.
Identifieur interne : 002437 ( Main/Exploration ); précédent : 002436; suivant : 002438Spectral clustering of fMRI data within regions of interest: clarification of L-dopa effects in Parkinson's disease.
Auteurs : Pamela W H. Lee [Canada] ; Z. Wang ; Samantha J. Palmer ; Martin J. MckeownSource :
- Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference [ 1557-170X ] ; 2007.
English descriptors
- KwdEn :
- Algorithms, Antiparkinson Agents (administration & dosage), Brain (drug effects), Brain (physiopathology), Brain Mapping (methods), Cluster Analysis, Humans, Image Interpretation, Computer-Assisted (methods), Levodopa (administration & dosage), Magnetic Resonance Imaging (methods), Parkinson Disease (drug therapy), Parkinson Disease (physiopathology), Prognosis, ROC Curve, Reproducibility of Results, Sensitivity and Specificity, Treatment Outcome.
- MESH :
- chemical , administration & dosage : Antiparkinson Agents, Levodopa.
- drug effects : Brain.
- drug therapy : Parkinson Disease.
- methods : Brain Mapping, Image Interpretation, Computer-Assisted, Magnetic Resonance Imaging.
- physiopathology : Brain, Parkinson Disease.
- Algorithms, Cluster Analysis, Humans, Prognosis, ROC Curve, Reproducibility of Results, Sensitivity and Specificity, Treatment Outcome.
Abstract
Identifying active regions of the brain that are task-related is important in fMRI study. Current methods of determining functional Regions of Interest (ROIs) are unsatisfactory because they either reduce the effect size or bias the statistical results. We propose a spectral clustering method for assessing those voxels within an ROI that are suitable for further task-activation analysis. Different similarity functions are studied and the correlation index is chosen based on the simulation study. In real fMRI study, further group analysis employing regression is investigated to identify different brain activation patterns between groups in order to reveal the effects of disease and medicine. A real fMRI case study in Parkinson's disease suggests that the technique is promising, warranting further study.
DOI: 10.1109/IEMBS.2007.4353522
PubMed: 18003188
Affiliations:
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Le document en format XML
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Palmer</name></author><author><name sortKey="Mckeown, Martin J" sort="Mckeown, Martin J" uniqKey="Mckeown M" first="Martin J" last="Mckeown">Martin J. Mckeown</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2007">2007</date><idno type="RBID">pubmed:18003188</idno><idno type="pmid">18003188</idno><idno type="doi">10.1109/IEMBS.2007.4353522</idno><idno type="wicri:Area/PubMed/Corpus">001107</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001107</idno><idno type="wicri:Area/PubMed/Curation">001107</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001107</idno><idno type="wicri:Area/PubMed/Checkpoint">001107</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001107</idno><idno type="wicri:Area/Ncbi/Merge">000837</idno><idno type="wicri:Area/Ncbi/Curation">000837</idno><idno type="wicri:Area/Ncbi/Checkpoint">000837</idno><idno type="wicri:doubleKey">1557-170X:2007:Lee P:spectral:clustering:of</idno><idno type="wicri:Area/Main/Merge">002661</idno><idno type="wicri:Area/Main/Curation">002437</idno><idno type="wicri:Area/Main/Exploration">002437</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Spectral clustering of fMRI data within regions of interest: clarification of L-dopa effects in Parkinson's disease.</title><author><name sortKey="Lee, Pamela W H" sort="Lee, Pamela W H" uniqKey="Lee P" first="Pamela W H" last="Lee">Pamela W H. Lee</name><affiliation wicri:level="1"><nlm:affiliation>Department of Electrical and Computer Engineering, University of British Columbia, Vancouver, BC, Canada. wpamelal@interchange.ubc.ca</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Electrical and Computer Engineering, University of British Columbia, Vancouver, BC</wicri:regionArea><wicri:noRegion>BC</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Z" sort="Wang, Z" uniqKey="Wang Z" first="Z" last="Wang">Z. Wang</name></author><author><name sortKey="Palmer, Samantha J" sort="Palmer, Samantha J" uniqKey="Palmer S" first="Samantha J" last="Palmer">Samantha J. Palmer</name></author><author><name sortKey="Mckeown, Martin J" sort="Mckeown, Martin J" uniqKey="Mckeown M" first="Martin J" last="Mckeown">Martin J. Mckeown</name></author></analytic><series><title level="j">Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. 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Current methods of determining functional Regions of Interest (ROIs) are unsatisfactory because they either reduce the effect size or bias the statistical results. We propose a spectral clustering method for assessing those voxels within an ROI that are suitable for further task-activation analysis. Different similarity functions are studied and the correlation index is chosen based on the simulation study. In real fMRI study, further group analysis employing regression is investigated to identify different brain activation patterns between groups in order to reveal the effects of disease and medicine. A real fMRI case study in Parkinson's disease suggests that the technique is promising, warranting further study.</div></front></TEI><affiliations><list><country><li>Canada</li></country></list><tree><noCountry><name sortKey="Mckeown, Martin J" sort="Mckeown, Martin J" uniqKey="Mckeown M" first="Martin J" last="Mckeown">Martin J. Mckeown</name><name sortKey="Palmer, Samantha J" sort="Palmer, Samantha J" uniqKey="Palmer S" first="Samantha J" last="Palmer">Samantha J. Palmer</name><name sortKey="Wang, Z" sort="Wang, Z" uniqKey="Wang Z" first="Z" last="Wang">Z. Wang</name></noCountry><country name="Canada"><noRegion><name sortKey="Lee, Pamela W H" sort="Lee, Pamela W H" uniqKey="Lee P" first="Pamela W H" last="Lee">Pamela W H. Lee</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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